Stability Over Spotlight: High-Dose Biotin’s Subtle Strength for MS
- Bridie Lindsay
- Jun 7
- 10 min read
Holding It Together from the Inside Out
“Sometimes, not getting worse is the biggest win.”
Living with a neurological condition like multiple sclerosis (MS) often means navigating unpredictability. Fluctuating symptoms, varying responses to treatments, and the emotional toll can be overwhelming. At Nuutree, we understand that stability—feeling "held together"—is invaluable. That's why we formulated Biotin100: to offer cellular-level support that aligns with emerging scientific insights, not just for beauty — hair, skin, and nails (and yes, mucosa too — wink wink — read more in our Mucosa Blog).
Over the last decade, researchers have been curious about what happens when you give the body far more biotin than the standard daily allowance. Not just for nails and hair, but for something deeper — like how the nervous system heals, adapts, or even stabilises.
Many of you may know that in clinical trials, high-dose biotin (labeled as MD1003) was investigated for its potential to support people living with progressive multiple sclerosis. The results varied, but they revealed something that can't be ignored.
In one small but meaningful pilot study by Sedel et al., 13 out of 23 people — around 57% — showed improvement in their MS symptoms. Notably, none of them got worse. In another study, Tourbah et al. found that 13% of patients taking high-dose biotin improved their disability scores compared to none in the placebo group. Others, like Birnbaum and Tourbah again in later research, observed visual improvements, stabilisation, and subtle but hopeful shifts in people’s experience of MS.
Even when walking speed improvements were reported over 12–15 months, as highlighted in a 2021 review, the tone from researchers was cautious — not because of harm, but because not every patient had the same experience.
The largest trial (SPI2, 2020) — a rigorous phase 3 study — did not show a statistically significant improvement in disability or walking speed. This was a turning point for the pharmaceutical path of MD1003, and many interpreted it as the end of the road for biotin as a treatment. But the full story is more nuanced. One death occurred during the trial in the MD1003 group, but investigators confirmed it was unrelated to the supplement. The cause of death was not attributed to biotin and details such as age or co-existing conditions were not disclosed — and sadly, we must remember that people with chronic, complex illnesses do sometimes pass away during studies for reasons unrelated to the intervention.
Crucially, the trial found no new safety concerns. And while the numbers didn’t meet the statistical thresholds required by pharma regulators, many participants still described feeling steadier, more energised, or simply reassured. The light at the end of the tunnel wasn’t extinguished — it just didn’t flash brightly enough for the official spotlight.
And in that tunnel, let us pause and honour the person whose life was lost during the trial. While their passing was not attributed to biotin and remains medically unrelated, their journey still matters. Every human life affected by chronic illness carries a weight — not just in the body, but in the spirit.
In that spirit, we offer a moment of unity consciousness — a prayer of remembrance for the soul who departed, and a healing intention for all those still walking the path of MS and other long-term health conditions. May strength ripple gently through your cells, and may peace find you in still moments. May you feel supported by the unseen frequencies of light, love, and resilience that travel farther than we ever realise.
This is not religion. This is resonance. A moment to send support — universally, inclusively — to all who need it - including ourselves.
That’s the thing about research: numbers can’t always measure the moments when someone feels a bit stronger, steadier, or more in tune with themselves. But people feel it.
Reading Between the Lines
The results within the trials may seem mixed, but they reflect a deeper truth: clinical trials don't always capture real-life wins. And those small wins are important.
MS is complex and influenced by:
co-existing health conditions
inflammation, stress, and lifestyle
dietary variation and nutrient absorption
Clinical outcomes like EDSS scores can't always reflect real improvements, such as:
improved bladder control
feeling more stable
less fatigue
fewer flare-ups
improved cognitive clarity
subtle improvements in gut, bladder, or emotional function
At Nuutree, we believe even a plateau can be powerful.
💚 Biotin100: Support Without the Smokescreen
We've also heard directly from clients who write in to tell us that they feel a difference. Many describe Biotin100 as something that gives them a subtle but reassuring sense of being supported — like the ground beneath them has steadied. It's not always easy to explain in clinical terms, but the lived experience of clarity, energy, or just feeling more 'held together' keeps coming up in feedback. And we listen.
Not every remedy needs a spotlight. Some are like roots — quietly strengthening from beneath, supporting growth even when it’s unseen.
And whilst you might’ve seen the name MD1003 in research and it may sound like a breakthrough drug, but it's just high-dose biotin labeled as MD1003 in the trials. And while we respect clinical innovation, we also believe in access and simplicity.
We made Biotin100 because my mum needed it. Then I needed it too — living with PFO, CFS, and ADHD. We’re not claiming miracles. We’re offering a nutritional tool designed to nourish the body from the inside out.
With Nuutree Biotin100 you get:
100mg of fermented, vegan D-biotin
over 99.5% purity, batch-tested
no fillers or fluff
a clean, transparent product that respects your body
When Action Feels Like Healing
We’ve heard from people who say:
"I didn’t get worse for the first time in years."
"My fatigue reduced."
"My bladder has improved control."
And that’s the spirit of Biotin100. Not flashy. Foundational.
It’s not just about the body — it’s about the brain-body-spirit connection. When you choose to take a supplement like Biotin100, or build a simple wellness routine, something powerful happens: you shift from helplessness to engagement. From drifting to anchoring.
This kind of intentional action is known to reduce mental health burden and emotional overwhelm in people with long-term or incurable conditions. It brings structure, purpose, and self-advocacy — all of which nourish the nervous system too. And when we nourish the nervous system the body has time to rest and repair.
And let’s not forget the wider ripples: partners, children, and caregivers often feel that same weight of uncertainty. Having something practical to do — something that offers many meaningful moments of support and stability — can uplift the wider circle of those affected by MS. That ripple of taking action reaches further than we think — from the individual to their partner, their children, friends, workplaces, and wider communities. We are all beacons for each other, often without even knowing it.
Did You Know?
Biotin isn’t just about beauty — it’s a coenzyme involved in key reactions throughout your body. Here are a few lesser-known facts:
Biotin supports over five major enzymes involved in metabolism and gene regulation.
It plays a direct role in fatty acid synthesis, needed for myelin repair and nerve insulation.
Biotin levels can be impacted by gut health, medications, and inflammation, all common challenges for people with chronic illness.
So even if your diet seems okay, your cells might be quietly calling out for more.
Safety Note - its important to debunk some myths
Some sources refer to “side effects” of high-dose biotin — but these are not toxicity-related. In fact, biotin has been shown to be safe at high doses in both research and practice.
The primary issue is that biotin can interfere with blood tests, especially thyroid, hormone, and cardiac biomarkers. This happens because some lab assays use biotin-based technology, and high blood levels can cause false positives or negatives.
The solution is simple: pause Biotin100 (and other high-dose supplements, drugs, or alcohol) for 72 hours before any blood tests. Your healthcare provider can help guide you. It's a known, manageable issue — not a danger in and of itself.
It’s a bit like trying to tune a radio while someone nearby is using a powerful signal booster — the test gets scrambled by a strong signal that isn’t part of what it was trying to read. The problem isn’t the radio, or you — it’s just interference that can be easily avoided with a little planning.
That’s the deal with high-dose biotin. It’s not harming your body. But it can throw off certain test results if your doctor doesn’t know you’re taking it — and that could lead to wrong diagnoses or unnecessary treatments.
So please: hit pause for 72 hours before bloodtests, and always let your healthcare team know. We trust our Nuutree community to honour this simple but crucial step - any non of our customers have reported an issue which highlights MS patients know how to navigate their health pathway when provided the right information.
If you’re looking for a supplement that respects your complexity, Biotin100 might be your quiet ally. (Please note that Subscriptions are not yet live however you can easily BUY NOW either one month or multibuy with savings by checking out securely with PayPal or email hello@nuutree.net and I will happily set you up on a manual monthly subscription meanwhile).
Small Steps That Support the Whole You
If you’re navigating MS or other long-term health challenges, there are gentle things you can do alongside Biotin100 that help the brain-body-spirit system feel held:
🌿 Stretching or restorative movement to calm the nervous system and improve circulation.
🌱 Magnesium-rich foods (like leafy greens, seeds, and dark chocolate) to support nerve health.
🎶 Sound healing or calming music to harmonise emotional tension and soothe the stress response (see below for more on this exciting research)
🌼 Nature connection, even if it’s just a potted herb or a birdsong video — to remind your cells they belong to something bigger.
These small things matter. They’re not fixes, but they are forms of care. And care creates change.
It’s not just about myelin support — although that’s an exciting part of the picture. Biotin100 also contributes to:
cellular energy production
enzyme function in metabolism
nervous system communication
gene regulation
immune balance
healthier skin, hair, nails and mucosal integrity
improved cognitive clarity
bladder function and muscular control
For some, it’s the stability. For others, it’s the subtle lift. For many, it’s the sense that something inside is finally being nourished.
Biotin100 doesn’t shout — it supports. And in a world that often overlooks subtlety, that’s a powerful thing.
Invitation - A Closing Breath for Rest and Repair
Before you go, I invite you to take a gentle moment for yourself — to honour your nervous system and the unseen work your body is doing every day.
The Universe sees you. We see you. This is a challenging pathway — undeserved, and too often under-served. What you carry is heavy. It lingers in the quiet spaces, casting a subtle shadow even across the brightest moments.
And yet, it’s within this very contrast — between light and dark — that the most radiant healing can emerge. The juxtaposition makes the light all the more luminous.
As we breathe, as we soften, as we reconnect with the now, our frequency shifts. Mind, body, and spirit begin to align. We remember: we are not alone. We are not broken. We are held.
You are loved. You are unique. And the Universe lives through you — each and every one of us — with every breath we take.
BREATHE in through your nose… softly count to four. Imagine oxygen flowing to the deepest parts of your nervous system — gently brushing over any damaged myelin, soothing the edges of inflammation.
HOLD for a moment… count to four. Picture your immune system easing into balance, your cells realising they are safe. The signal is calm now.
EXHALE slowly through your mouth… count to six. Let go of tension. Imagine energetic healing sweeping along your neural pathways — soft light touching every junction, every scarred place, every misfiring neuron. See the light not just soothe, but also reset — gently recalibrating what was once erratic, and laying the foundation for new, more harmonious signals to build and flow. Bathe in the light.
Repeat for three cycles.
You might like to visualise a soft golden thread moving up your spine — weaving new space between thought, breath, and being.
This isn’t about doing it perfectly — it’s about letting your body feel heard.
May this breath be a reminder that healing isn’t always loud. Sometimes it hums quietly, deep within. You may even wish to pair this breathwork with a healing frequency, like 528 Hz, often called the 'miracle tone' for its potential cellular support and resonance with DNA and nervous system healing. You can find 528 Hz tracks easily on platforms like Spotify, YouTube, and many meditation apps for free, making it simple to create a calm, supportive soundscape at home.
Just so that you feel informed, please know that studies into sound therapy and meditation in MS suggest benefits such as reduced stress, improved focus, emotional resilience, and even neuroplasticity - the brain’s ability to rewire itself, form new neural connections, and adapt to changes or healing.
The study "Music-based therapy in rehabilitation of people with multiple sclerosis" highlights several benefits of music-based therapy (MBT) for individuals with MS: Motor Function Improvements: Enhancements in gait, balance, and coordination Emotional Well-being: Reduction in anxiety and depression symptoms. Cognitive Benefits: Improvements in attention and memory. Pain Management: Decreased perception of pain: So quite a big deal really!
When your navigating MS or any other complex chronic disease small shifts are key to building hope and more positive outcomes. I for one, feel the difference and uplift from incorporating meditation and healing frequencies into the everyday of my life and recommend MBT wholeheartedly to the Nuutree community.
For those looking to try a DIY version of Music-Based Therapy (MBT), consider:
Listening to rhythmic, instrumental music daily
Using guided music meditations or neurologic music therapy playlists
Playing simple instruments like drums, chimes, or handpans to engage motor and emotional pathways
Incorporating voice toning, chanting, or singing along (linking to 'Polyvagal toning' - more on that in an upcoming blog)
These practices may help ease the burden on an overstimulated immune system while gently reinforcing new patterns of calm and clarity. The key is intentional, repeated engagement with sound and perhaps gentle rhythmic movement that brings your system into coherence — which you can do from the comfort of your own space.
It’s an exciting and expanding area of research — with sound and frequency therapies being explored not just for MS, but also for PTSD, anxiety, insomnia, and even cellular regeneration. While science is still catching up to what many intuitively feel, early studies continue to show promising results.
These findings suggest that MBT can be a valuable component of a comprehensive MS rehabilitation program. For more detailed information, you can explore the full study here via the link above or here: Music-based therapy in rehabilitation of people with multiple sclerosis.
And if nothing else, may this breath be your quiet reminder:
“I am building my resilience as a human — from the inside out. Not for perfection. Not for applause. But because I am worthy of care, of light, and of the life I am still here to live.”
This blog is for educational purposes and is not medical advice. Nuutree does not claim to treat or cure any illness. Please consult your doctor before starting supplements. Thank you for supporting a small wellbeing brand. Bridie - Founder, Nuutree
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